If you’re anything like me, you spend a significant portion of the day wondering about the paths viruses take when they’re cruising around your internals. Luckily for us, a newly developed microscope from Duke researchers can show the exact path taken by the little critters (?), down to the micrometer.
The system, designed by a team led by assistant professor Kevin Welsher, isn’t like a traditional microscope. Instead of magnifying an image using natural or augmented light, it scans a laser through a small volume repeatedly and from multiple angles. This illuminates special fluorescent particles, the positions of which can be tracked over time hotel in hong kong.
Attach one of those particles to something else and you can track what it’s doing. It’s kind of like a mocap studio for microbiology. But until recently, those particles were too big to attach to viruses — imagine trying to do your Gollum impression with basketballs taped all over your body. Welsher’s team recently improved the power of the system enough that it can detect much smaller dots — and even fluorescent proteins built right into the virus’s system. The result, as you see up top, is quite a detailed little track!
Simple, right?
I’m reminded of the old Family Circus cartoons, with Billy or whoever going all over the neighborhood, petting dogs, tracking mud on the neighbor’s porch and so on. Except Billy is a lentivirus, and the neighborhood is the soupy exterior of a cell membrane present ideas for boyfriend
.
It’s not all just for kicks, of course: The goal is to be able to watch as a virus makes contact with a cell and does whatever it does to penetrate and infect it. That moment, so critical to understanding viral behavior, is poorly understood because it’s been nearly impossible to observe directly.
“What we are trying to investigate is the very first contacts of the virus with the cell surface — how it calls receptors, and how it sheds its envelope,” said Welsher in a Duke news release. “We want to watch that process in real time, and to do that, we need to be able to lock on to the virus right from the first moment.”
With this system, we’re a step closer to understanding one of the most sophisticated biological machines ever created. The team’s work is published this week in the journal of the Optical Society Managed VPN .
2015年4月26日星期日
Rajeeb Dey’s new career platform Learnerbly secures £1.6M led by Frontline Ventures
Professional development is one of the hot areas for big corporates grappling with their millennials influx who are hungry to learn, so it makes sense that new platforms are now appearing to service this need.
Today, Learnerbly, a “curated professional development SaaS platform” based in London announces that it has raised £1.6 million in seed financing to create a so-called Development Management System. The round was led by Frontline Ventures, while other participants in the London headquartered start-up funding round include Playfair Capital, the Mayor of London’s London Co-Investment Fund (LCIF), Future Planet Capital and UK tech angels including Stephan Thoma, former Global Learning and Development director, Google; Renaud Visage, co-founder, Eventbrite; Jason Stockwood, CEO, Simply Business; and Claire Davenport, CEO, HelloFresh UK. It already has clients including IDEO, carwow, and ustwo Virtual Private Network
The founder and CEO is Rajeeb Dey MBE, a high-profile person in the UK tech community after previously founding Enternships, a portal which connected students and graduates to internships and graduate jobs in startups and fast growing businesses. For that he became a Young Global Leader (YGL) for the World Economic Forum in 2012 and the youngest recipient of the Queen’s Award for Enterprise Promotion in 2013.
Enternships will be the parent company/legal entity for Learnerbly, while Enternships will remain as a free to use, self-service jobs platform for startups/SMEs.
The idea is that Learnerbly allows SMEs to manage the development of their staff using personal development planning tools which flex around their personal needs. Employees are matched to learning opportunities and these are curated via peer-to-peer recommendations and insights from over 100 industry experts from companies including Google, Airbnb, AKQA and Unruly reenex. Over 50% of the learning recommendations are either free or cheap to access.
The market for professional learning is highly fragmented and small businesses can rarely access the “Learning Management Systems (LMS)” aimed at big companies. This is a market also being attacked by the UK-based Smartup.io which this year raised $5.5m. In addition, competitors Degreed and Sequoia-backed Everwise are focused on the enterprise and are both US-based.
Learnerbly takes a bottom-up approach, allowing employees to learn however they choose — whether it’s by reading a book or article, attending a course or watching a TED talk. Employers cam also give employees learning budgets who can then spend that on courses, conferences, books and coaching through the platform. HR departments get given a view of the choices and the platform captures feedback on all internal and third-party learning opportunities and uses this to recommend the best resources and ascertain the return on investment.
Dey told me he saw the need after working on Enternships and seeing that the people placed into internships needed more professional development as they grew Cruises from Hong Kong. “Despite nearly $360bn being spent globally by businesses in 2016 on professional development, there is still a disconnect between spend, activity and impact. Learnerbly leverages expert insights and brings transparency to expenditure by continuously assessing the efficacy of all forms of learning activities. By placing our focus on the application rather than solely the acquisition of knowledge we are able to evaluate the impact of learning both for the employee and the business. We are creating a new category in the industry which we are calling a Development Management System,” he says.
William McQuillan, Partner at Frontline Ventures says: “Millennials do not look at a job as a job for life, but instead as a stepping stone. Learning and development are therefore crucial to them when considering which employers they want to join or stay with.”
Today, Learnerbly, a “curated professional development SaaS platform” based in London announces that it has raised £1.6 million in seed financing to create a so-called Development Management System. The round was led by Frontline Ventures, while other participants in the London headquartered start-up funding round include Playfair Capital, the Mayor of London’s London Co-Investment Fund (LCIF), Future Planet Capital and UK tech angels including Stephan Thoma, former Global Learning and Development director, Google; Renaud Visage, co-founder, Eventbrite; Jason Stockwood, CEO, Simply Business; and Claire Davenport, CEO, HelloFresh UK. It already has clients including IDEO, carwow, and ustwo Virtual Private Network
The founder and CEO is Rajeeb Dey MBE, a high-profile person in the UK tech community after previously founding Enternships, a portal which connected students and graduates to internships and graduate jobs in startups and fast growing businesses. For that he became a Young Global Leader (YGL) for the World Economic Forum in 2012 and the youngest recipient of the Queen’s Award for Enterprise Promotion in 2013.
Enternships will be the parent company/legal entity for Learnerbly, while Enternships will remain as a free to use, self-service jobs platform for startups/SMEs.
The idea is that Learnerbly allows SMEs to manage the development of their staff using personal development planning tools which flex around their personal needs. Employees are matched to learning opportunities and these are curated via peer-to-peer recommendations and insights from over 100 industry experts from companies including Google, Airbnb, AKQA and Unruly reenex. Over 50% of the learning recommendations are either free or cheap to access.
The market for professional learning is highly fragmented and small businesses can rarely access the “Learning Management Systems (LMS)” aimed at big companies. This is a market also being attacked by the UK-based Smartup.io which this year raised $5.5m. In addition, competitors Degreed and Sequoia-backed Everwise are focused on the enterprise and are both US-based.
Learnerbly takes a bottom-up approach, allowing employees to learn however they choose — whether it’s by reading a book or article, attending a course or watching a TED talk. Employers cam also give employees learning budgets who can then spend that on courses, conferences, books and coaching through the platform. HR departments get given a view of the choices and the platform captures feedback on all internal and third-party learning opportunities and uses this to recommend the best resources and ascertain the return on investment.
Dey told me he saw the need after working on Enternships and seeing that the people placed into internships needed more professional development as they grew Cruises from Hong Kong. “Despite nearly $360bn being spent globally by businesses in 2016 on professional development, there is still a disconnect between spend, activity and impact. Learnerbly leverages expert insights and brings transparency to expenditure by continuously assessing the efficacy of all forms of learning activities. By placing our focus on the application rather than solely the acquisition of knowledge we are able to evaluate the impact of learning both for the employee and the business. We are creating a new category in the industry which we are calling a Development Management System,” he says.
William McQuillan, Partner at Frontline Ventures says: “Millennials do not look at a job as a job for life, but instead as a stepping stone. Learning and development are therefore crucial to them when considering which employers they want to join or stay with.”
2015年4月23日星期四
Irish Coffee Cupcakes
In celebration of Saint Patrick's Day, we've reimagined the traditional drink as a cupcake for grown-ups. The moist, delicate cupcakes are flavored with espresso and brown sugar and topped with billowy whipped-cream frosting Dream beauty pro spiked with whiskey. A dusting of espresso powder makes a festive finish.
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Nutritional Information
Calories --
Total Fat --
Saturated Fat --
Cholesterol --
Sodium --
Total Carbohydrate --
Dietary Fiber --
Sugars --
Protein --
Calcium --
irish coffee cupcakes
Courtesy of Martha Stewart Living
Yields: 15
Oven Temp: 350
Ingredients
U.S. Metric Conversion chart
Cupcakes
2 cup(s) all-purpose flour
1 teaspoon(s) baking powder
1/4 teaspoon(s) baking soda
1/4 teaspoon(s) salt
1/2 cup(s) boiling water
2 tablespoon(s) instant-espresso powder
1/4 cup(s) whole milk
1 stick(s) unsalted butter, room temperature
1/2 cup(s) granulated sugar
1/2 cup(s) packed light brown sugar
2 large eggs
Frosting
1 cup(s) heavy cream
1 tablespoon(s) confectioners' sugar
1 tablespoon(s) whiskey
Instant-espresso powder, for dusting
Directions
Preheat oven to 350 degrees F. Make the cupcakes: Whisk together Dream beauty pro flour, baking powder, baking soda, and salt. Pour water over espresso powder; let cool. Combine espresso with milk. Beat butter and granulated and brown sugars with a mixer on medium speed until pale and fluffy, about 3 minutes. Add eggs, 1 at a time, beating well after each addition. Beat in flour mixture in 3 additions, alternating with espresso-milk mixture, beginning and ending with flour (batter may look broken).
Fill 15 cups (of two 12-cup muffin tins) three-quarters full. Bake until a toothpick inserted into the centers comes out clean, 20 to 22 minutes. Let cool; turn out cupcakes from tins.
Make the frosting: Whisk together cream and confectioners' sugar until Dream beauty pro medium peaks form. Add whiskey; whisk until slightly stiff peaks form.
Top each cupcake with 2 tablespoons frosting; dust with espresso powder.
2015年4月20日星期一
The boat swing Pleione
In the still of the night, on the tops of the trees, I quietly in the window. Out the window the moonlight as water, think and you in the together day, those with happiness and tears of dribs and drabs, memory is adding a touch of bright and warm. If you stand in front of me, always smiled at me, let me indulge in the misty mountains, my mind is also such as the agitation.
In your mountain mist in the ups and downs, once vibrant, because you encounter has become the dream of paradise, howling winds violent rain are hidden. I am your moment in the Qin Shiming month on an oath, you are my in Han pass near a willow tree; you are my hope from the Tang Dynasty in the Millennium millennium of waiting, you are my hidden in a ballad song. Today I want to tell you, Dream beauty proI have to sit on, you made for me on the boat, thousands of miles across the float to you sweet dreams, I am in your window singing softly, could not bear to wake up; you call my name, in whispering: I really miss you! The crystal clear tear drops on your face, in my heart flow together into a river, the wind, a familiar taste, you...... At that moment, smile on my face, his eyes full of tears have wet clothes.
"Love is long, can not load so many parting sorrow. Look at the clouds dancing sleeves at the peak. The boat, how do wild goose poetry sac bursts of sound of tears flow? Cloud, too long. Wandering heart still remember the peach tree of the oath, now to late autumn. Maple Leaf fluttering autumn day, when he cut a total of west window candle, in accordance with the chrysanthemum wine...... "Each of you wrote to me and look into a set of lines, my heart is like a thousand years of pain. You were flying in the poetry in the poetic romance blossoming, Dream beauty pro you running with gentleness, became my exhausted when the rest of the warm harbor. I'm just an ordinary woman, has been reluctant to believe that the causal past lives, but because of your poems I believe we agreed in previous life. Walk into your world, I turned away from the Red Fairy, non staining. And I love the daughter heart bathed in you unlimited warmth in my life, my life has added a romance of a gentle.
Perhaps, is really to wait for your arrival, think, think you hand over my parted bangs, listen to the whisper of a few words you, hope several eyes gleaming smile, wet eyes slowly over the red candle tears, her thoughts keep outside the fragrant path, slowly started life if the first meet scrolls, the interpretation of this life with you the story, then, on your name! On the willow, Dream beauty pro thousands of miles of the moon!
Perhaps, this bit of affection and warmth in this world will be fragrant, at midnight, tears. No matter how busy world, no matter how cold and warm heart, you are the most warm and cold when I love a.
In your mountain mist in the ups and downs, once vibrant, because you encounter has become the dream of paradise, howling winds violent rain are hidden. I am your moment in the Qin Shiming month on an oath, you are my in Han pass near a willow tree; you are my hope from the Tang Dynasty in the Millennium millennium of waiting, you are my hidden in a ballad song. Today I want to tell you, Dream beauty proI have to sit on, you made for me on the boat, thousands of miles across the float to you sweet dreams, I am in your window singing softly, could not bear to wake up; you call my name, in whispering: I really miss you! The crystal clear tear drops on your face, in my heart flow together into a river, the wind, a familiar taste, you...... At that moment, smile on my face, his eyes full of tears have wet clothes.
"Love is long, can not load so many parting sorrow. Look at the clouds dancing sleeves at the peak. The boat, how do wild goose poetry sac bursts of sound of tears flow? Cloud, too long. Wandering heart still remember the peach tree of the oath, now to late autumn. Maple Leaf fluttering autumn day, when he cut a total of west window candle, in accordance with the chrysanthemum wine...... "Each of you wrote to me and look into a set of lines, my heart is like a thousand years of pain. You were flying in the poetry in the poetic romance blossoming, Dream beauty pro you running with gentleness, became my exhausted when the rest of the warm harbor. I'm just an ordinary woman, has been reluctant to believe that the causal past lives, but because of your poems I believe we agreed in previous life. Walk into your world, I turned away from the Red Fairy, non staining. And I love the daughter heart bathed in you unlimited warmth in my life, my life has added a romance of a gentle.
Perhaps, is really to wait for your arrival, think, think you hand over my parted bangs, listen to the whisper of a few words you, hope several eyes gleaming smile, wet eyes slowly over the red candle tears, her thoughts keep outside the fragrant path, slowly started life if the first meet scrolls, the interpretation of this life with you the story, then, on your name! On the willow, Dream beauty pro thousands of miles of the moon!
Perhaps, this bit of affection and warmth in this world will be fragrant, at midnight, tears. No matter how busy world, no matter how cold and warm heart, you are the most warm and cold when I love a.
2015年4月2日星期四
Rhubarb Popsicles
These creative little pops are packed with bold flavors,dr max and can easily be made in quarter-pint mason jars — serve them right in the jars for a rustic-chic twist.
Courtesy of Local Kitchen
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Nutritional Information
Calories --
Total Fat --
Saturated Fat --
Cholesterol --
Sodium --
Total Carbohydrate --
Dietary Fiber --
Sugars --
Protein --
Calcium --
cranberry orange rhubarb popsicles
Courtesy of Local Kitchen
Yields: 8
Ingredients
U.S. dr max Metric Conversion chart
12 ounce(s) rhubarb pulp (2 pounds of stewed rhubarb, drained for juice)
1 cup(s) orange juice
1/2 cup(s) fine-grain sugar
2 tablespoon(s) fine-grain sugar
2 tablespoon(s) tequila
1 tablespoon(s) lime juice
1 cup(s) cranberries (frozen)
Directions
Blend rhubarb pulp, orange juice, sugar, tequila, and lime.dr max Add cranberries and process until mixture turns pink with bits of cranberry visible. Spoon into molds. Allow to freeze partially (about 1 hour) before adding popsicle sticks.
2015年3月18日星期三
Fruitful Morning Muesli
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Nutritional Information
Calories 300
Total Fat 4g
Saturated Fat 1g
Cholesterol 5mg
Sodium 45mg
Total Carbohydrate 62g
Dietary Fiber 5g
Sugars 30g
Protein 9g
Calcium 127g
fruitful morning muesli
Courtesy of Quaker Oats
Serves: 4
Yields: 4 servings
Ingredients
U.S. Metric Conversion chart
2 cup(s) Quaker? Oats (quick hong kong company formation or old fashioned) , uncooked
2 cup(s) apple juice or apricot nectar
1 1/2 cup(s) sliced fresh fruit (any combination of banana, peaches, nectarines or strawberries)
1 carton(s) (8-ounce) vanilla low-fat yogurt
2 tablespoon(s) chopped nuts (optional)
Directions
Combine all ingredients except nuts; mix well.
Cover; refrigerate 8 hours or overnight.
Serve cold; sprinkle with nuts, if desired. Refrigerate iaas in airtight container up to 4 days.
Nutrition Information per Serving: Vitamin A: 0%, Vitamin C: 10%, Calcium: 15%, Iron: 15%, Dietary Exchange: 2 starch, 1/2 non-fat milk, 2 fruit
2015年3月2日星期一
Supreme Pizza
This loaded pizza is a decadent, rich, sausage-and-veggie-topped feast.
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Nutritional Information
Calories 565
Total Fat 27g
Saturated Fat 11g
Cholesterol 66mg
Sodium 1,660mg
Total Carbohydrate 54g
Dietary Fiber 3g
Sugars --
Protein 22g
Calcium --
meat lovers supreme pizza
Johnny Miller
Serves: 4
Ingredients
U.S. Metric Conversion chart
1 1/4 pound(s) pizza dough, туры в Гонконг fresh or frozen (thawed)
3/4 cup(s) marinara sauce
6 ounce(s) fresh mozzarella cheese
4 ounce(s) sweet Italian sausage meat, casing removed
1 cup(s) sliced mushrooms
1 small green pepper, thinly sliced
3 ounce(s) pepperoni, sliced
3 strip(s) crumbled cooked bacon, optional
Directions
Place large cookie sheet in oven. Preheat oven to 475 degrees F.
Stretch dough round into small circle. Place on large sheet nuskin parchment paper, stretching and pressing to form 14-inch circle with slight rim. Spread sauce on dough; top with mozzarella in single layer. Transfer, with parchment, to hot cookie sheet.
Microwave, in medium microwave-safe bowl, 4 ounces sweet reenex hong kong Italian sausage meat, casing removed, on high 2 minutes or until no longer pink. Cool.
Top pizza with mushrooms, green pepper, pepperoni, and crumbled cooked bacon (optional). Crumble sausage on top.
Bake 20 to 22 minutes or until vegetables are tender and sausage is cooked.
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